TUdatalib : Chromatin reorganization as a major factor in the control of nuclear stiffness

Zur Kurzanzeige

dc.contributor.author	Romero, Hector
dc.contributor.author	Amiri, Anahid
dc.contributor.author	Pabba, Maruthi Kumar
dc.contributor.author	Zhang, Hui
dc.contributor.author	Berg, Veronika
dc.contributor.author	Arroyo, Maria
dc.contributor.author	Prorok, Paulina
dc.contributor.author	Trautwein, Nina
dc.contributor.author	Laube, Bodo
dc.contributor.author	Dietz, Christian
dc.contributor.author	Stark, Robert W.
dc.contributor.author	Cardoso, M. Cristina
dc.date.accessioned	2024-11-13T08:30:15Z
dc.date.available	2024-11-13T08:30:15Z
dc.date.issued	2024
dc.identifier.uri	https://tudatalib.ulb.tu-darmstadt.de/handle/tudatalib/4381
dc.description	DNA organization on chromatin has been largely studied for its consequences in gene expression, but its contribution to the cell mechanics is often neglected despite the nucleus being the stiffest organelle in the cell. Here, we show that MeCP2 directly increases the nuclear stiffness in a similar fashion as it clusters the heterochromatin. Moreover, we show how this phenomenon occurs during cellular differentiation and how it can be disrupted by mutations related to diseases.	de_DE
dc.language.iso	en	de_DE
dc.rights	Creative Commons Attribution-NonCommercial 4.0
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/
dc.subject	MeCP2	de_DE
dc.subject	mechanobiology	de_DE
dc.subject	stiffness	de_DE
dc.subject	atomic force microscope	de_DE
dc.subject	Rett syndrome	de_DE
dc.subject	chromatin organization	de_DE
dc.subject	neuronal differentiation	de_DE
dc.subject	myogenic differentiation	de_DE
dc.subject.classification	2.11-02 Biophysik	de_DE
dc.subject.classification	2.11-03 Zellbiologie	de_DE
dc.subject.ddc	570
dc.title	Chromatin reorganization as a major factor in the control of nuclear stiffness	de_DE
dc.type	Dataset	de_DE
tud.project	DFG \| CA198/16-1 \| Rölle und Regulation	de_DE
tud.project	DFG \| CA198/19-1 \| Wie die Zusammensetz	de_DE
tud.unit	TUDa