Chromatin reorganization as a major factor in the control of nuclear stiffness
Description
DNA organization on chromatin has been largely studied for its consequences in gene expression, but its contribution to the cell mechanics is often neglected despite the nucleus being the stiffest organelle in the cell. Here, we show that MeCP2 directly increases the nuclear stiffness in a similar fashion as it clusters the heterochromatin. Moreover, we show how this phenomenon occurs during cellular differentiation and how it can be disrupted by mutations related to diseases.
Subject
MeCP2;mechanobiology;stiffness;atomic force microscope;Rett syndrome;chromatin organization;neuronal differentiation;myogenic differentiationDFG subject classification
2.11-02 Biophysik2.11-03 Zellbiologie
Related third party funded projects
DFG | CA198/16-1 | Rölle und RegulationDFG | CA198/19-1 | Wie die Zusammensetz
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Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial 4.0