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dc.contributor.authorMamberti, Stefania
dc.contributor.authorPabba, Maruthi K.
dc.contributor.authorRapp, Alexander
dc.contributor.authorCardoso, Cristina
dc.contributor.authorScholz, Michael
dc.date.accessioned2022-04-04T08:48:25Z
dc.date.available2022-02-28T16:27:50Z
dc.date.available2022-04-04T08:48:25Z
dc.date.issued2022
dc.identifier.citationThe Chromatin Architectural Protein CTCF Is Critical for CellSurvival upon Irradiation-Induced DNA Damage. Stefania Mamberti, Maruthi K. Pabba, Alexander Rapp, M. Cristina Cardoso and Michael Scholz Int. J. Mol. Sci. 2022, 23, 3896. https://doi.org/10.3390/ijms23073896
dc.identifier.urihttps://tudatalib.ulb.tu-darmstadt.de/handle/tudatalib/3405.2
dc.descriptionCTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact its DNA binding sites are enriched at the borders of chromatin domains. Recently, we showed that depletion of CTCF impairs the DNA damage response to ionizing radiation. To investigate the relationship between chromatin domains and DNA damage repair, we present here clonogenic survival assays in different cell lines upon CTCF knockdown and ionizing irradiation. The application of a wide range of ionizing irradiation doses (0-10 Gy) allowed us to investigate the survival response through a biophysical model that accounts for the double strand breaks probability distribution onto chromatin domains. We demonstrate that the radiosensitivity of different cell lines is increased upon lowering the amount of the architectural protein. Our model shows that the deficiency in DNA repair ability is related to the changes in the size of chromatin domains that occur when different amounts of CTCF are present in the nucleus.de_DE
dc.language.isoende_DE
dc.relationIsCitedBy;DOI;10.3390/ijms23073896
dc.rightsCreative Commons Attribution-NonCommercial 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectcancerde_DE
dc.subjectchromatin architecturede_DE
dc.subjectchromatin loopde_DE
dc.subjectclonogenic survivalde_DE
dc.subjectCTCFde_DE
dc.subjectDNA damage responsede_DE
dc.subjectDNA repairde_DE
dc.subjectionizing radiationde_DE
dc.subjectphysical modelingde_DE
dc.subject.classification201-03 Zellbiologiede_DE
dc.subject.ddc570
dc.titleThe chromatin architectural protein CTCF is critical for cell survival upon irradiation-induced DNA damagede_DE
dc.typeSoftwarede_DE
dc.typeImagede_DE
dc.typeModelde_DE
dc.description.versionPublished Versionde_DE
tud.projectDFG | GRK1657 | GRK 1657 TP1Cde_DE
tud.projectDFG | SFB1361,TP06 | TP_06_Cardoso_Mainzde_DE
tud.projectDFG | GRK1657TP2C | GRK 1657 TP 2Cde_DE
tud.projectDFG | CA198/9-2 | Hochauflösende Analyde_DE
tud.projectDFG | CA198/15-1 | Regulation der Säugede_DE
tud.unitTUDa


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